Finasteride
CAS No. : 98319-26-7
(Synonyms: MK-906)
| Size | Price | Stock |
|---|---|---|
| 100mg | $60 | In-stock |
| 200mg | $96 | In-stock |
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| Cat. No. : | HY-13635 |
| M.Wt: | 372.54 |
| Formula: | C23H36N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
Finasteride (MK-906) is an orally active and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].
IC50 & Target:IC50: 4.2 nM (type II 5α-reductase)[1]
In Vitro:Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum[1].
In Vivo:Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration[3].
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