Hupehenine
CAS No. : 98243-57-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $250 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N0413 |
| M.Wt: | 415.65 |
| Formula: | C27H45NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders[1][2][3][4].
In Vitro: Hupehenine (24 h) can inhibit α-synuclein seeded fibril formation in vitro[1].
Hupehenine (2-10 µM; 48 h) does not significantly reduce α-synuclein seed-induced cytotoxicity in SH-SY5Y cells[1].
Hupehenine (7.2-14.4 µM; 48 h) can induce the elevation of ROS levels, loss of mitochondrial membrane potential, cell cycle arrest, as well as autophagy and apoptosis in Leishmania donovani promastigotes[2].
In Vivo: Pharmacokinetic Analysis in Rats[3]
| Route | Dose (mg/kg) | AUC0-t (ng/mL h) | AUC0-∞ (ng/mL h) | t1/2 (h) | CL (L/h/kg) | V (L/kg) | Cmax (ng/mL) | Bioavailability, F |
| p.o. | 10 | 935.6 | 1097.4 | 5.4 | 11.5 | 91.5 | 390.2 | 13.4% |
| i.v. | 5 | 3494.9 | 3514.3 | 4..6 | 1.5 | 9.9 | 1400.5 |