Lomefloxacin (hydrochloride)

Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma ^{[1][2][3][4][5][6]}. IC50 & Target:MIC₉₀: 0.12 mg/L (Haemophilus influenzae), 0.25 mg/L (Moraxella catarrhalis), 0.06 mg/L (Legionella pneumophila)^[1] In Vitro:Lomefloxacin (1/4 to 2×MIC concentrations) hydrochloride rapidly reduces viable cell counts of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, with no regrowth observed in all strains except P. aeruginosa^[1].
Lomefloxacin hydrochloride exhibits MIC values ranging from 0.06-4 μg/mL in susceptibility determination experiments with strains such as Escherichia coli and Staphylococcus aureus^[2].
Lomefloxacin (0.1-1.0 mM; 24-72 h) hydrochloride decreases viability of COLO829 cells and induces ROS production in COLO829 cells^[3].
Lomefloxacin (50-100 μM) hydrochloride induces apoptosis in keratinocyte^[4].
In Vivo:Lomefloxacin (ED₅₀: 1.45-32.2 mg/kg; p.o.; immediately after infection) hydrochloride significantly reduces mortality in mice with intraperitoneal infection models, with ED₅₀ values lower than those of Ofloxacin and Norfloxacin^[1].
Lomefloxacin (-80 mg/kg; orogastric administration) hydrochloride reduces mortality, significantly decreases splenic bacterial counts, and inhibits inflammatory response in mice infected with Salmonella typhimurium^[5].
Lomefloxacin (16-32 mg/kg; i.p.; 5 days) hydrochloride only at the highest dose slightly reduces the number of implants and live fetuses in the third week of mating in mice, without significant dominant lethal mutation induction^[6].