Fosinopril
CAS No. : 98048-97-6
(Synonyms: SQ28555 (free acid))
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| Cat. No. : | HY-B0690 |
| M.Wt: | 563.66 |
| Formula: | C30H46NO7P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fosinopril (SQ28555 free acid) is the ester prodrug of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM[1][2].
IC50 & Target: IC50: 0.18 μM[1]; Ki: 1.675 μM[2]
In Vitro: Fosinopril (0-100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2[1].
Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2[1].
Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM[2].
In Vivo: Fosinopril (4.67 mg/kg; p.o.; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and againsts cardiac dysfunction and structural alteration in rat[3].
Fosinopril (4.67 mg/kg; p.o.; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model[3].
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