2-Pyrazinecarboxylic acid

2-Pyrazinecarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. In Vitro: Pyrazinecarboxylic acid is an active metabolite of pyrazinamide. Pyrazinamidean is an anti-tubercular agent. In this model for the evaluation of the effects of uricosuric agents, the urinary excretion of pyrazinecarboxylic acid was decreased by probenecid and indic ated an inverse correlation between urinary excretion of urate and pyrazinecarboxylic acid. In the in vitro study, the treatment of the vesicles of rat renal brush-border membrane with pyrazinecarboxylic acid produced an increased urate uptake, which was inhibited by uricosuric agents. PZA (pyrazinamide) is con verted to pyrazinecarboxylic acid (POA) in plant cells, suppressing the activity of 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), the enzyme catalysing the final step of ethylene formation.