Pyrazinamide
CAS No. : 98-96-4
(Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide)
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 100g | $50 | In-stock |
| 500g | $95 | In-stock |
| 1000g | $187 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-B0271 |
| M.Wt: | 123.11 |
| Formula: | C5H5N3O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;H2O : 6.67 mg/mL (ultrasonic) |
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2]. IC50 & Target: IC50: Mycobacterium tuberculosis[1] In Vitro: Pyrazinamide exhibits remarkable activity in vivo activity, has no activity against growing Mycobacterium tuberculosis except at an acidic pH. In M. tuberculosis, acidic pH enhances the intracellular accumulation of pyrazinoic acid (POA), the active derivative of PZA.POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis[1].
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