Nicotinamide
CAS No. : 98-92-0
(Synonyms: Niacinamide; Nicotinic acid amide)
| Size | Price | Stock |
|---|---|---|
| 500mg | $25 | In-stock |
| 1g | $35 | In-stock |
| 5g | $50 | In-stock |
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| Cat. No. : | HY-B0150 |
| M.Wt: | 122.13 |
| Formula: | C6H6N2O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity[1][2][3][4].
In Vitro:Nicotinamide (0-50 mM, 24/48 h ) reduces cell number in a time-dependent and dose-dependent manner in A375 and SK-MEL-28 cells[1].
Nicotinamide (10-50 mM, 24 h ) makes A375 cells undergo accumulation in G1 phase, reduction in S phase, and increase inthe sub-G1 (apoptosis) phase[1].
Nicotinamide (1-50 mM, 6 h ) increases NAD+, ATP and ROS levels in A375 and SK-MEL-28 cells[1].
Nicotinamide Hydrochloride (0.01-20 mM, 1 h) inhibits purified SIRT2 enzymatic activity in vitro with an EC50 of 2 μM[1].
Nicotinamide (0-64 mM) inhibits HBV replication in HepAD38 and HepG2.2.15 cells[3].
Nicotinamide (10 mM, on day 13) promotes pancreatic cell differentiation from human embryonic stem cells (hESCs) through CK1 and ROCK inhibition[4].
In Vivo:Nicotinamide (Intraperitoneal injection, 1500 and 1800 mg/Kg, 5 days per week) inhibits tumor growth in murine metastatic melanoma model[1].
Nicotinamide (Intraperitoneal injection, 1800 mg/Kg, once a day, murine metastatic melanoma model) affects IFN-γ (a key mediator of cell-mediated anti-tumor immunity), increases the plasma levels of Eotaxin and IL-5, reduces the plasma levels of IL-3, IL-12, RANTES and IL-10[1].
Nicotinamide (vein injection, 0-200 mg/kg, 5 days) inhibits HBV replication in HBV-transgenic mice[3].
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