α-Terpineol

α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation^{[1][2][3][4][5][6][7]}. In Vitro:α-Terpineol (1-10 µM, 20 h) exerts anti-inflammatory effects in LPS-stimulated mouse peritoneal macrophages by inhibiting the NF-κB signaling pathway^[4].
α-Terpineol (0.06-0.125% v/v, 48 h) inhibits the growth of G. vaginalis (MIC = 0.06%) and C. albicans (MIC = 0.125%), showing antimicrobial activity comparable to Clotrimazole (HY-10882) ((v/v) represents volume/volume concentration, indicating the proportion of α-Terpineol in the culture medium)^[4].
α-Terpineol (1-100 μM, 24 h) inhibits AMPK phosphorylation, activates SREBP-1, and promotes lipid synthesis in HepG2 cells^[7]. In Vivo:α-Terpineol (6.25-50 mg/kg, p.o., single administration) exhibits antidiarrheal activity by exerting anticholinergic effects, blocking PGE2 and GM1 receptors, and interacting with cholera toxin, thereby reducing castor oil-induced diarrhea in a mouse model of acute diarrhea^[5].
\ α-Terpineol (56 mg/kg, i.p., single administration) provides short-term relief of mechanical pain in a mouse model of neuropathic pain induced by chronic constriction injury^[6].
α-Terpineol (100 mg/kg and 500 mg/kg, p.o., once daily for 2 weeks) induces fatty liver and promoted hepatic lipid accumulation in C57BL/6 mice^[7].