Sophoraflavanone G
CAS No. : 97938-30-2
(Synonyms: Kushenol F)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 20mg | $220 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $630 | In-stock |
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| Cat. No. : | HY-N1231 |
| M.Wt: | 424.49 |
| Formula: | C25H28O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2]. IC50 & Target: IC50: 29.7 μM (MDA-MB-231 cell)[1] In Vitro: Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells?in a dose-dependent manner[1]. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome?c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway[1] Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>
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