Chloroquinoxaline sulfonamide
CAS No. : 97919-22-7
(Synonyms: Chloroquinoxaline; NSC-339004)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $300 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $1050 | In-stock |
| 100mg | $1680 | In-stock |
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| Cat. No. : | HY-106662 |
| M.Wt: | 334.78 |
| Formula: | C14H11ClN4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle[1]. Antitumor activity[2].
In Vitro: The Chloroquinoxaline sulfonamide IC50?for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links[1].
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used[2].
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