Nafagrel
CAS No. : 97901-21-8
(Synonyms: DP-1904 (free acid))
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| Cat. No. : | HY-106111 |
| M.Wt: | 256.31 |
| Formula: | C15H16N2O2 |
| Purity: | >98 % |
| Solubility: |
Nafagrel (DP-1904 free acid) is a Thromboxane A2 synthase inhibitor. Nafagrel inhibits the production of Thromboxane A2 and increases the production of Prostaglandin I2 (HY-A0126A). Nafagrel prevents thrombotic material accumulation in acute arterial thrombosis models. Nafagrel can be used in research on peripheral vascular disease, restenosis after PTCA, and lupus nephritis[1][2][3].
In Vitro:Nafagrel inhibits thromboxane synthase as an imidazole derivative[1].
DP-1904 (0.1 μM-1 mM; 2 h) completely suppresses TXB2 production and dramatically increases 6-keto-PGF1α production from human umbilical vein EC and platelets stimulated by HA-IgG in a coculture system, acting as a TXA2 synthetase inhibitor[3].
In Vivo:Nafagrel inhibits the accumulation of thrombotic material in a rat model of acute arterial thrombosis, whereas ASA is ineffective[1].
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