SAH
CAS No. : 979-92-0
(Synonyms: SAH (S-Adenosylhomocysteine))
| Size | Price | Stock |
|---|---|---|
| 100mg | $237 | In-stock |
| 250mg | $528 | In-stock |
| 1g | $1427 | In-stock |
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| Cat. No. : | HY-19528 |
| M.Wt: | 384.41 |
| Formula: | C14H20N6O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C) |
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
In Vitro:SAH (10-7-10-5 M) activates norepinephrine (NE) and serotonin (5-HT) in vitro uptake in synaptosomal preparations from rat brain, but does not affect dopamine (DA) uptake[1].
SAH (0.1-10 μM) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 μM in Kinetic parameter determination of the METTL3-14 complex[2].
In Vivo:SAH (administered i.v., i.p. or p.o. in 1-10 mg/kg) is sleep-inductive and anticonvulsant with rabbit, rat and cat[1].
SAH (intraperitoneal injection; 7 mg/kg; 1 h prior to sacrifice) induces in vitro uptake increase for NE and 5-HT, significant only in brain stem and midbrain, but does not alter DA uptake[1].
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