Penciclovir (sodium)
CAS No. : 97845-62-0
(Synonyms: VSA 671 (sodium); BRL 39123A; BRL 39123D)
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| Cat. No. : | HY-107739 |
| M.Wt: | 275.24 |
| Formula: | C10H14N5NaO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2].
In Vitro: Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells[1].
In Vivo: Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2].
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