Eticlopride (hydrochloride)
CAS No. : 97612-24-3
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| Cat. No. : | HY-103413 |
| M.Wt: | 377.31 |
| Formula: | C17H26Cl2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1-adrenergic, α2-adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride hydrochloride is an antipsychotic agent[1].
In Vitro:Eticlopride (1 μM, 6 h) hydrochloride abrogates the action of DA, where DA increases KLF2 expression in HUVEC cells[2].
Eticlopride (1 μM, 15 min) hydrochloride abolishes heterodimerization of D2R/SSTR2 in rat striatal neurons[3].
In Vivo:Eticlopride (10 mg/kg, i.p.) hydrochloride blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing mice[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) hydrochloride alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].
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