Canrenone
CAS No. : 976-71-6
(Synonyms: Aldadiene; SC9376)
| Size | Price | Stock |
|---|---|---|
| 50mg | $50 | In-stock |
| 100mg | $80 | In-stock |
| 500mg | $160 | In-stock |
| 1g | $240 | In-stock |
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| Cat. No. : | HY-B1438 |
| M.Wt: | 340.46 |
| Formula: | C22H28O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent. IC50 & Target: Target: Aldosterone[1] In Vitro: Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner[1]. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor[2]. In Vivo: Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone[3].
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