Troglitazone
CAS No. : 97322-87-7
(Synonyms: CS-045)
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $112 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $710 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-50935 |
| M.Wt: | 441.54 |
| Formula: | C24H27NO5S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Troglitazone is an orally active PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes.
IC50 & Target:EC50: 550 nM (Human PPARγ), 780 nM (Murine PPARγ)[1]
In Vitro:Troglitazone (2-200 μM, 24 h) is cytotoxic to the pancreatic cancer cell lines (MIA Paca2 and PANC-1 cells), with IC50s of 49.9±1.2 and 51.3±5.3 μM, respectively[2].
Troglitazone (50 μM, 24 h) increases chromatin condensation in MIA Paca2 and PANC-1 cells, enhances the activity of caspase-3 and decreases Bcl-2 expression[2].
Troglitazone (0-4 μM, 12 h) sensitizes TRAIL-mediated apoptosis in human lung adenocarcinoma cells (A549, HCC-15 and
Calu-3)[3].
Troglitazone (0-4 μM, 12 h) induces autophagy and sensitized apoptosis mediated by TRAIL in A549 cells[1].
In Vivo:Troglitazone (200 mg/kg, p.o., every day for 5 weeks) shows inhibitory effects on the growth of tumor in the MIA Paca2 xenograft model[2].
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