Topiramate
CAS No. : 97240-79-4
(Synonyms: McN 4853; RWJ 17021)
| Size | Price | Stock |
|---|---|---|
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| 500mg | $297 | In-stock |
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| Cat. No. : | HY-B0122 |
| M.Wt: | 339.36 |
| Formula: | C12H21NO8S |
| Purity: | >98 % |
| Solubility: | H2O : 4 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL |
Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3]. IC50 & Target: GluR5 receptor[1]; GABAergic[2]; Kainate/AMPA[2]; Sodium channel[2]; Calcium channel[2]; Potassium channel[2]; Carbonic anhydrase[2] In Vitro: Topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors[2].
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