BBMP
CAS No. : 97120-13-3
(Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone)
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| Cat. No. : | HY-108984 |
| M.Wt: | 343.20 |
| Formula: | C12H11BrN2O3S |
| Purity: | >98 % |
| Solubility: |
BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research[1]. In Vitro:BBMP is effective in both swelling and membrane potential assays displaying pIC50 values of 5.5 and 5.6, respectively. BBMP dose-dependently prevents DNA fragmentation induced by KCl 25/5 mM shift and serum deprivation in cerebellar granule neurons with a pIC50 of 5.7. The inhibition of PTP-mediated cytochrome c release observed in isolated mitochondria at 10 and 100 μM may explain its neuroprotective properties in vitro[1].
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