Itaconic acid
CAS No. : 97-65-4
(Synonyms: Methylenesuccinic acid)
| Size | Price | Stock |
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| Cat. No. : | HY-Y0520 |
| M.Wt: | 130.10 |
| Formula: | C5H6O4 |
| Purity: | >98 % |
| Solubility: | H2O : 27.78 mg/mL (ultrasonic) |
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].
In Vitro:Itaconic acid (2–8 mM, 24 h) induces ferroptosis by activating ferritinophagy in PANC1 cells[3].
Itaconic acid (10 mM, 24 h) inhibits LPS-induced inflammatory cytokines in RAW264.7 cells[4].
Itaconic acid (10 mM, 24 h) promotes the pentose phosphate pathway (PPP) and NADPH oxidase activity in RAW264.7 cells[4].
Itaconic acid (10 mM, 24-72 h) inhibits cell viability of cerebellar granule cells (CGC) and inhibits ADP-stimulated respiration in permeabilized CGC cells[5].
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