Ditolylguanidine
CAS No. : 97-39-2
(Synonyms: 1,3-Di-o-tolylguanidine; DTG)
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| Cat. No. : | HY-14218 |
| M.Wt: | 239.32 |
| Formula: | C15H17N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer[1][2][3][4]. IC50 & Target:Sigma receptor[1] In Vitro:Ditolylguanidine (39-60 nM) dose-dependently inhibits N-(2-piperidinoethyl)4-iodobenzamide) (IPAB) with a Ki value of 40 nM[2]. Ditolylguanidine inhibits small cell lung cancer cells lines NCI-N417 and NCI-H209 with IC50 values of 100 and 90 nM, respectively[3]. Ditolylguanidine (0-10 μM) shows Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively[4]. In Vivo:Ditolylguanidine (i.v.; 1-5 mg/kg, once) affects micturition intervals and the threshold pressure of anaesthetized rats[1]. Ditolylguanidine (intracerebroventricular administration; 1 μg, once) extends micturition intervals and raises the threshold pressure of anaesthetized rats[1].
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