Bithionol
CAS No. : 97-18-7
| Size | Price | Stock |
|---|---|---|
| 500mg | $60 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-17592 |
| M.Wt: | 356.05 |
| Formula: | C12H6Cl4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL |
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM)[1][2].
IC50 & Target:Adenylyl cyclase[2]
In Vitro:Bithionol (0.1-10 mg/mL, 72 h) shows toxicity to Neoparamoeba spp parasites in sea water[1].
Bithionol (0-100 μM) inhibits adenylyl cyclase (AC) activity with an IC50 value of 4 μM[2].
Bithionol (50 and 100 μM, 0-10 min) decreases in cAMP formation with essentially complete inhibition of sAC-dependent cAMP accumulation in sAC-overexpressing 4-4 cells[2].
In Vivo:Bithionol (100 mg/kg/day, oral administration for 12 days) is moderately active against immature H. nana in mice[3].
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