Momordin Ic

Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity^[1][2].
In Vitro:Momordin Ic (0-20 μM, 48 h) relies on cholesterol and ganglioside GM1 to enhance the toxicity of recombinant protein MAP30 in breast cancer cells^[2].
Momordin Ic (10 μM, 24 h) induces colon cancer cell cycle arrest and apoptosis by inhibiting the SENP1/c-MYC signaling pathway^[3].
In Vivo:Momordin Ic (12.5, 25, 50 mg/kg, p.o.) accelerates gastrointestinal transport and inhibits gastric emptying in mice by stimulating the synthesis of serotonin (5-HT)^[4].
Momordin Ic (10 mg/kg, p.o.) can inhibit ethanol induced gastric mucosal lesions in rats^[5].
Momordin Ic (30 mg/kg, once a day for 14 days, p.o.) can reduce CCl₄-induced hepatotoxicity in rats^[6].