Cyproheptadine (hydrochloride)
CAS No. : 969-33-5
(Synonyms: Cyproheptadine HCl)
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| Cat. No. : | HY-B0366A |
| M.Wt: | 323.86 |
| Formula: | C21H22ClN |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders[1][2].
IC50 & Target: 5-HT2A receptor[1]
In Vitro: Cyproheptadine hydrochloride (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro[2].
Cyproheptadine hydrochloride (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro[2].
Cyproheptadine hydrochloride inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro[2].
In Vivo: Cyproheptadine hydrochloride (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo[2].
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