Orlistat
CAS No. : 96829-58-2
(Synonyms: Tetrahydrolipstatin; Ro-18-0647)
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 200mg | $103 | In-stock |
| 500mg | $185 | In-stock |
| 1g | $240 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-B0218 |
| M.Wt: | 495.73 |
| Formula: | C29H53NO5 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity[1]. Anti-atherosclerotic effect[2]. In Vitro: Orlistat (40 μM; 2 days) does not affect MGMT levels in a human melanoma cell line, but downregulates the repair protein by 30-70% in human peripheral blood mononuclear cells, in two leukemia and two colon cancer cell lines. Orlistat does not alter noticeably MGMT mRNA expression[1]. In Vivo: Orlistat (10 mg/kg/day) significantly improves lipid profile, increases antioxidant enzymes and expression of anti-inflammatory markers, and decreases the expression of the pro-inflammatory marker compared to the obese (OB) group[2].
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