Deoxynyboquinone
CAS No. : 96748-86-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $590 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $1710 | In-stock |
| 50mg | $2750 | In-stock |
| 100mg | $4380 | In-stock |
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| Cat. No. : | HY-108992 |
| M.Wt: | 284.27 |
| Formula: | C15H12N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C) |
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation[1][2][3].
IC50 & Target: Apoptosis[2][3]; ROS[4]
In Vitro: Deoxynyboquinone (DNQ; 72h) potently induces the death of cancer cells (SK-MEL-5, MCF-7, HL-60, HL-60/ADR) in culture, with IC50 values between 16 and 210 nM[2].
Deoxynyboquinone is still able to induce cancer cell death under hypoxic conditions (HeLa cell; IC50: 5.1 μM)[2].
Deoxynyboquinone (group B1; 0.5 μM; 3, 6, 24 hours) potently induces apoptosis in cancer cell lines (MCF-7, HL-60) through cytochrome c release[3].
In Vivo: Deoxynyboquinone (2.5, 5, and 10 mg/kg; every other day for 5 injections; i.v. for day 2-18) shows antitumor efficacy confirmed by overall survival (at 5 mg/kg), at a 6-fold lower dose than β-lapachone (30 mg/kg)[4].
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