[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
CAS No. : 96736-12-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $95 | In-stock |
| 5mg | $225 | In-stock |
| 10mg | $335 | In-stock |
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| Cat. No. : | HY-103544 |
| M.Wt: | 1516.83 |
| Formula: | C79H109N19O12 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer[1][2][3]
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