RPH-2823
CAS No. : 96558-24-6
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| Cat. No. : | HY-101595 |
| M.Wt: | 370.41 |
| Formula: | C17H22N8O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance[1]. In Vitro: RPH-2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1]. In Vivo: RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].
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