Pyridaben
CAS No. : 96489-71-3
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| Cat. No. : | HY-B0817 |
| M.Wt: | 364.93 |
| Formula: | C19H25ClN2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[1][2].
In Vitro:Pyridaben (0-10 µM; 3 min) selectively inhibits complex I-III in rat brain submitochondrial particles[1].
Pyridaben (0-10 µM; 3 min) leads to marked decrease in respiratory control (IC50 = 1.7 µM) in a dose-dependent manner, in rat brain mitochondria (malate-glutamate as substrate)[1].
Pyridaben (0-10 µM; 3 min) produces a marked decrease in mtNOS functional activity, when malate-glutamate is used as substrate, but not when the substrate is succinate.[1].
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