Irindalone
CAS No. : 96478-43-2
(Synonyms: Lu 21-098)
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| Cat. No. : | HY-101632 |
| M.Wt: | 408.51 |
| Formula: | C24H29FN4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Irindalone is a novel serotonin 5-HT2 antagonist. IC50 & Target: 5-HT2[1] In Vitro: Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1]. In Vivo: Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].
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