Isothiafludine
CAS No. : 960527-22-4
(Synonyms: NZ-4)
| Size | Price | Stock |
|---|---|---|
| 1mg | $350 | In-stock |
| 5mg | $866 | In-stock |
| 10mg | $1184 | In-stock |
| 25mg | $1824 | In-stock |
| 50mg | $2376 | In-stock |
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| Cat. No. : | HY-111003 |
| M.Wt: | 375.48 |
| Formula: | C18H18FN3OS2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation[1].
In Vitro:Isothiafludine inhibits HBV DNA replication, with an IC50 of 1.33 μM[1].
Isothiafludine (8 days) shows an IC50 (50% cytotoxicity) of 50.4 μM against HepG2.2.15 cells[1].
Isothiafludine (1.25-20 μM, 48 h) also inhibits the replication of 3TC/ETV-dual-resistant and ADV-resistant HBV mutants in virus transfected Huh7 cells[1].
Isothiafludine (10-20 μM, 8 days) decreases the levels of encapsidated HBV pgRNA in HepG2.2.15 cells[1].
In Vivo:Isothiafludine (p.o., 25-100 mg/kg, for 15 days) inhibits DHBV DNA replication in a DHBV-infected duck model[1].
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