Dapagliflozin ((2S)-1,2-propanediol, hydrate)
CAS No. : 960404-48-2
(Synonyms: BMS-512148 (2S)-1,2-propanediol, hydrate)
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $58 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $121 | In-stock |
| 100mg | $154 | In-stock |
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| Cat. No. : | HY-10450A |
| M.Wt: | 502.98 |
| Formula: | C24H35ClO9 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 2.38 mg/mL (ultrasonic) |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2]. In Vitro: Dapagliflozin ((2S)-1,2-propanediol, hydrate) (0-10 μM; 24 hours) significantly increases the cell survival in hypoxic HK2 cell in a dose-dependent manner[2].Dapagliflozin ((2S)-1,2-propanediol, hydrate) (0-10 μM; 2 hours) increases the HIF1 expression, increases AMPK and EKR phosphorylation in hypoxic HK2 cells, but shows no effect on the phosphorylation of AMPK and ERK in normoxic HK2 cells[2].
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