Have any questions? [email protected] +86-21-58998590
Structure search

Fc 11a-2


CAS No. : 960119-75-9

960119-75-9
Price and Availability of CAS No. : 960119-75-9
Size Price Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-111662
M.Wt: 236.31
Formula: C16H16N2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 960119-75-9 :

Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis[1][2][3]. In Vitro:Fc 11a-2 (10 μM) suppresses the release of IL-1β and IL-18 from LPS (HY-D1056)-primed THP-1 cells activated with ATP exhibiting an IC50 of about 10 μM[1]. In Vivo:Fc 11a-2 (3-30 mg/kg; Orally; from day 1 to day 10) dose-dependently attenuates the loss of body weight and shortening of colon length induced by DSS[2].

Your information is safe with us.