2,4-Di-tert-butylphenol

2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances^[1][2][3]. In Vitro:2,4-Di-tert-butylphenol (10 μM; 14 d) can increase adipogenesis in human mesenchymal cells, with the same effect as PPARγ agonist (500 nM; 14 d)^[2].
2,4-Di-tert-butylphenol (10 μM; 14 d) can also increase adipogenesis that is blocked by PPARγ antagonist T0070907 (HY-13202) (10 μM) or RXRα antagonist HX531 (HY-108521) (1 μM)^[2].
2,4-Di-tert-butylphenol can also activate PPARγ and RXRα in human COS-7 cells^[2].
In Vivo:2,4-Di-tert-butylphenol (300 mg/kg/day; po; 28 d) causes hepatotoxicity (associated with centrilobular hypertrophy of hepatocytes, which results in liver weight gain) and nephrotoxicity in rats, and increases cholesterol and phospholipids in female rats^[2].
2,4-Di-tert-butylphenol (5-40 mg/kg/day; po; 28 d) can significantly attenuate Aβ_1-24-induced cognitive impairment and exert an anti-amnestic effect^[3].