Guggulsterone
CAS No. : 95975-55-6
(Synonyms: Z/E-Guggulsterone)
| Size | Price | Stock |
|---|---|---|
| 1mg | $36 | In-stock |
| 5mg | $60 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $390 | In-stock |
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| Cat. No. : | HY-107738 |
| M.Wt: | 312.45 |
| Formula: | C21H28O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic) |
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1][2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively[3]. In Vitro:Guggulsterone (0.5-20 μM; 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS[2]. In Vivo:Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2].
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