Swinholide A
CAS No. : 95927-67-6
| Size | Price | Stock |
|---|---|---|
| 10μg | $271 | Get quote |
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| Cat. No. : | HY-111009 |
| M.Wt: | 1389.87 |
| Formula: | C78H132O20 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM[1]. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity[2].
In Vitro: Swinholide A, first isolated from the Okinawan marine sponge Theonella swinhoei, dimerizes actin[1].
Swinholide A, isolated from the marien sponge Theonella swinhoei, is highly cytotoxic to a variety of cancer cell lines[2].
Swinholide A disrupts the actin cytoskeleton of cells grown in culture, sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers with a binding stoichiometry of one swinholide A molecule per actin dimer, and rapidly severs F-actin in vitro with high cooperativity[2].
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