Sotalol (hydrochloride)

Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent^[1][2][3]. IC50 & Target:β-adrenergic receptor^[1]; Potassium channels^[1] In Vivo: Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin^[3].