Afegostat (D-Tartrate)
CAS No. : 957230-65-8
(Synonyms: D-Isofagomine (D-Tartrate); Isofagomine (D-Tartrate))
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| Cat. No. : | HY-14829E |
| M.Wt: | 297.26 |
| Formula: | C10H19NO9 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL |
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1]. IC50 & Target: GCase[1] In Vivo: Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].
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