Betamethasone (hydrochloride)
CAS No. : 956901-32-9
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| Cat. No. : | HY-13570A |
| M.Wt: | 428.92 |
| Formula: | C22H30ClFO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].
In Vitro: Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis[4].
In Vivo: Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation[1].
Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain[2].
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