SB-633825
CAS No. : 956613-01-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $105 | In-stock |
| 5mg | $260 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $800 | In-stock |
| 50mg | $1280 | In-stock |
| 100mg | $2100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108333 |
| M.Wt: | 483.58 |
| Formula: | C28H25N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 9.62 mg/mL (ultrasonic) |
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].
IC50 & Target: IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK)[1]
In Vitro: SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1].
SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].
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