Ranolazine (dihydrochloride)
CAS No. : 95635-56-6
(Synonyms: CVT 303 (dihydrochloride); RS 43285)
| Size | Price | Stock |
|---|---|---|
| 100mg | $80 | In-stock |
| 200mg | $120 | In-stock |
| 500mg | $211 | In-stock |
| 1g | $264 | In-stock |
| 5g | $594 | In-stock |
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| Cat. No. : | HY-17401 |
| M.Wt: | 500.46 |
| Formula: | C24H35Cl2N3O4 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL;DMSO : ≥ 50 mg/mL |
Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3]. IC50 & Target: IC50: 6 μM (INa), 12 μM (IKr)[1] In Vivo: Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion[3].
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