PI-3065
CAS No. : 955977-50-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $260 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $695 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12235 |
| M.Wt: | 506.64 |
| Formula: | C27H31FN6OS |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM. IC50 & Target: IC50: 5 nM (p110δ), 910 nM (p110α), 600 nM (p110β), >10000 nM (p110γ)[1] In Vitro: PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ[1]. In Vivo: PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss[1].
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