Fosfenopril
CAS No. : 95399-71-6
(Synonyms: Fosinoprilat; Fosinoprilic acid; SQ 27519)
| Size | Price | Stock |
|---|---|---|
| 5mg | $270 | In-stock |
| 10mg | $435 | In-stock |
| 25mg | $865 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-107352 |
| M.Wt: | 435.49 |
| Formula: | C23H34NO5P |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes[1][2].
In Vitro: Fosfenopril (0-10 μM, 5 min) inhibits the expression of TLR4 which is elevated by LPS[1].
Fosfenopril (0-10 μM, 1 h)attenuates the expression of NF-κB which is activated by LPS[1].
Fosfenopril inhibits LPS-induced cytokines (IL-6, IL-1β, and TNF-α) expression[1].
In Vivo: Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min, IV, once) increases p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) in dogs[3].
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