L524-0366


CAS No. : 951612-19-4

951612-19-4
Price and Availability of CAS No. : 951612-19-4
Size Price Stock
1mg $140 In-stock
5mg $300 In-stock
10mg $460 In-stock
25mg $790 In-stock
50mg $1100 In-stock
100mg $1450 In-stock
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Cat. No. : HY-113763
M.Wt: 308.79
Formula: C13H13ClN4OS
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 951612-19-4 :

L524-0366 is a specific, dose-dependent TWEAK-Fn14 inhibitor. L524-0366 specifically binds to the Fn14 surface with a KD of 7.12 μM, competitively inhibiting the binding of Fn14 to TWEAK (inhibition rate reaching 16%). L524-0366 inhibits TWEAK-induced glioma cell migration without potential cytotoxic effects[1]. IC50 & Target:TWEAK-Fn14[1] In Vitro: L524-0366 (20 μM) effectively inhibits TWEAK-induced NF-κB activation and luciferase activity in a dose-dependent manner[1].

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