Perindoprilat


CAS No. : 95153-31-4

(Synonyms: S 9780)

95153-31-4
Price and Availability of CAS No. : 95153-31-4
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Cat. No. : HY-B1433
M.Wt: 340.41
Formula: C17H28N2O5
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 250 mg/mL (ultrasonic)
Introduction of 95153-31-4 :

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2]. In Vitro: Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells[2]. Perindoprilat (40 μM, 3 days) treatment attenuates mesangial cell fibronectin level[3]. In Vivo: Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction[4].

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