Tafamidis meglumine
CAS No. : 951395-08-7
(Synonyms: Fx-1006A)
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $240 | In-stock |
| 100mg | $350 | In-stock |
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| Cat. No. : | HY-14852A |
| M.Wt: | 503.33 |
| Formula: | C21H24Cl2N2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic);H2O : ≥ mg/mL |
Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1].
IC50 & Target: EC50: 2.7-3.2 μM (TTR)[1]
In Vitro: Tafamidis binds selectively and with negative cooperativity (Kds ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR[1].
Tafamidis (0-7.2 μM) dose-dependently inhibits WT-TTR amyloidogenesis after treatment for 72 hours at a pH of 4.4-4.5[1].
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