Desformylflustrabromine hydrochloride
CAS No. : 951322-11-5
(Synonyms: Deformylflustrabromine hydrochloride; dFBr hydrochloride)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $95 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $305 | In-stock |
| 100mg | $485 | In-stock |
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| Cat. No. : | HY-107675 |
| M.Wt: | 357.72 |
| Formula: | C16H22BrClN2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 105 mg/mL;H2O : 5 mg/mL (ultrasonic) |
Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48. IC50 & Target: α4β2 nAChR In Vitro: Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48[1]. ACh-induced currents are potentiated and inhibited by Desformylflustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform (pEC50=6.4±0.2) compare with the HS isoform (pEC50=5.6±0.2). Desformylflustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%)[2].
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