LMD-009
CAS No. : 950195-51-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $380 | In-stock |
| 10mg | $650 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-121885 |
| M.Wt: | 471.59 |
| Formula: | C29H33N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM[1]. In Vitro:LMD-009 (0-20 nM; 90 min) stimulates inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor[1]. LMD-009 (0-100 nM; 1 h) mediates calcium release in Chinese hamster ovary cells[1]. LMD-009 (0.1 nM-100 μM; 40 min) induces L1.2 cells migration[1]. LMD-009 (0-10 μM; 90 min) exhibits different molecular interaction with CCR8 mutations in COS-7 cells[1]. LMD-009 (0-10 nM; 90 min) exhibits no antagonist activity to other human chemokine receptors[1].
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