Methylhydroquinone
CAS No. : 95-71-6
| Size | Price | Stock |
|---|---|---|
| 25g | $15 | In-stock |
| 100g | $31 | In-stock |
| 500g | $66 | In-stock |
| 1000g | $110 | In-stock |
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| Cat. No. : | HY-W012817 |
| M.Wt: | 124.14 |
| Formula: | C7H8O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2]. In Vivo:Methylhydroquinone (200 mg/kg; gastric intubation, single dose) induces DNA single-strand breaks and increases ornithine deoxycholate (ODC) activity and repetitive DNA synthesis (RDS) in rat gastric pyloric mucosa[2].
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