Spirapril (hydrochloride)
CAS No. : 94841-17-5
(Synonyms: SCH 33844 (hydrochloride))
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| Cat. No. : | HY-A0230A |
| M.Wt: | 503.07 |
| Formula: | C22H31ClN2O5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1]. IC50 & Target: IC50: angiotensin converting enzyme[1] In Vivo: Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]
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