ML365
CAS No. : 947914-18-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $165 | In-stock |
| 50mg | $265 | In-stock |
| 100mg | $420 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12345 |
| M.Wt: | 360.41 |
| Formula: | C22H20N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels[1].
IC50 & Target: IC50: 4 nM (TASK1/KCNK3), 390 nM (TASK3/KCNK9)[1]
In Vitro: ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM)[1].
ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG)[1].
ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM[1].
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